Janice secretly maxes out her credit card in the purchase of an American Gal doll and accessories and takes a job as Ernesto's housekeeper to earn some extra cash. Bud, however puts in motion a plan to get her fired, while Gert seeks revenge on the American Gal company.
Bud helps a Mexican “Bud” look-alike sneak over the border, so he can take a break from his own life.
Bud unwittingly becomes drug kingpin Pablo Barracuda’s inside man at the Border Station, as he competes to be richer and more successful than Ernesto.
Frustrated that J.C. still hasn't gotten a job, Ernesto hires him as part of his landscaping crew. When the job turns out too difficult, J.C. unionizes Ernesto's workers and begins a strike.
The Mexifornia population tips from white majority to Latino majority when Maria's sister has a baby, so Bud wants Janice to have another baby in order to even the shift.
Bud becomes the high school football coach after the previous coach is forced out of the job by the local redneck fans.
The comedy, which takes place in a fictitious desert town near the U.S.-Mexico border, centers on the intertwining daily lives of neighbors Bud Buckwald and Ernesto Gonzales. Bud, a married father of three, is a Border Patrol agent who feels threatened by the cultural changes that have transformed his neighborhood. Living next door is Ernesto, an industrious Mexican immigrant and father of four, who is proud to be making it in America. As Bud and Ernesto’s paths begin to cross, their families become bound by friendship, romance and conflict.