After losing his wife seven years earlier, the eccentric Dr. John Dolittle, famed doctor and veterinarian of Queen Victoria’s England, hermits himself away behind the high walls of Dolittle Manor with only his menagerie of exotic animals for company. But when the young queen falls gravely ill, a reluctant Dolittle is forced to set sail on an epic adventure to a mythical island in search of a cure, regaining his wit and courage as he crosses old adversaries and discovers wondrous creatures.
A successful physician and devoted family man, John Dolittle seems to have the world by the tail, until a long suppressed talent he possessed as a child, the ability to communicate with animals is suddenly reawakened with a vengeance! Now every creature within squawking distance wants the good doctor's advice, unleashing an outrageous chain of events that turns his world upside down!
Lisa Dolittle sends her daughter to 'Durango', a Dude Ranch, to find herself. While there, she uses her talent to talk to the animals in order to save Durango from being taken over by a neighboring Ranch.
A group of beavers ask Dr. Dolittle to save their habitat from loggers. The only hope is to get the forest preserved because it's the home of a protected bear, but there's a problem: the bear's the only bear in the forest, so she can't reproduce. Undaunted, Dolittle persuades a circus bear to help out, but he has to teach him not just the ways of the wild, but the wiles of lady bears too.
Maya Dolittle is back in a heartwarming adventure of presidential proportions! Maya's dream of going to vet school is put on hold when she gets a call from the president of the United States. It seems the First Dog is out of control, and the president needs Maya's help. It's up to Maya and her own dog, Lucky, to stop a canine catastrophe from becoming a national crisis!