Shido, Yayoi, Riho and Guni are on a building top where a breed has possessed a woman and she has a hostage. After talking the woman is released and Shido kills the breed. He thinks to himself about a past incident that relates to the recent battle.
A girl, Yuki says she found the pendant that she's wearing around her neck. A guy with wings like an angel appears from the pendant and says that he will bring her happiness.
Shido's a midnight detective, half human and half vampire with no real memory of his past, who specializes in solving supernatural murders.Joined by Yayoi Matsunaga, a female government agent, Riho Yamazaki, an orphaned teenage girl working as his secretary and Guni, a little green imp, Shido must face demonic creatures known as Nightbreed.