Tyrannical Boston financier Jackson C. Revere travels West to confront his son, who has pledged to support himself in Mineral City despite his father's lack of faith in his abilities.
Big Jim Moran, former town bum, has struck it rich with a uranium mine, thus inspiring Pat Brady to sell Nellybelle and purchase a geiger counter. Unfortunately, both Moran and Pat are attacked by a vicious gang of claim-jumpers.
Doc Buckland orders George Hooper's herd destroyed because of hoof-and-mouth disease, thus jeopardizing the impending sale of Hooper's ranch. Hooper's foreman murders the doctor and frames Dave Shelton, a mute who expresses himself through his paintings.
Johnny Williams, son of a poor storekeeper, hopes to attend college, but his father cannot finance his education unless he joins his unscrupulous partner in a smuggling scheme.
A young witness whose testimony can send the Collins gang to prison is pursued by the outlaws who hope to silence her permanently.
Roy's summer camp for underprivileged youngsters is plagued by the presence of a surly juvenile delinquent named Mick, who falls in with a gang of badmen trying to recover stolen loot concealed in a mine tunnel on Roy's property.
Colonel Mattock, an old cattle baron, wants to rid the region of the Pinto Basin nesters. He is unaware, however, of his foreman's activities for his own selfish purposes.
A little girl is the pawn in a family feud over ownership of a silver mine.
An influential rancher accuses a young Indian of murdering the town blacksmith. Roy comes to the young man's defense and eventually proves him innocent.
Roy discovers that the stock of a mountain fishing preserve is rapidly and mysteriously dwindling. The only witness to the poching is an old miner who is so intimidated by the crooks that he feigns amnesia.
When Clark Baxter is released from jail, he vows to seek vengeance against fisherman Joe Herkimer. Kerkimer's testimony had sent him to jail. Baxter and his thugs rob an old recluse and frame Kerkimer, whom Roy and Pat must clear of the false charge.
Amity Bailey and her husband Ezra have been wed for thirty years, during which they've been fantasizing about a European honeymoon they could never afford. When they assist in capturing three thieves, the sheriff gives them a reward which allows them to fulfill their dream.
Roy Rogers is the owner of the RR Ranch in the Mineral City area, which he runs with the help of the German shepherd dog Bullet and his horse Trigger. Roy, supported by his friend Pat Brady, is often helping the weakest usually threatened by cattle thieves, dishonest sheriffs and villains of various kinds. Pat Brady works as a cook at the Eureka Café, owned by Dale Evans.