With Dante impaled and crucified in the demon dimension, it's up to Lady, Trish, Morrison and Patty to hold off Sid/Abigail's final assault on the world.
Dante encounters Patty's mother, and Sid's carefully laid plans come to fruition as he finally harnesses the power of Abigail, a demon that fought against Mundus.
Dante is attacked by Barusa, a former servant of Sparda who now seeks the power of the Legendary Dark Knight. In the meantime, Barusa's brother tries to find a way to prevent the fight between Dante and Barusa.
A man named Aaron keep on insisting that Dante is his childhood friend Tony and that he and his mother used to live in a small town before being banished by the town folks after a devil attacked the town 20 years ago.
Dante finds himself followed by a customer from a local diner, who is trying to find out the devil hunter's secrets, in order to impress a local waitress whom he likes.
Lady meets up with a strange demon-woman who has a lightning-like technique. Later it's revealed that the strange woman is Trish, Dante's former partner.