The Tick and Arthur end up in the distant past and uncover a diabolical plot by the Hotel Manager, a man from the future using prehistoric man as staff for his Hotel at the beginning of the universe. They manage to defeat him and free man's ancestors from a life of low-paying minimum wage jobs.
The Tick and Arthur are invited to the Mad Scientist Fair to help Dr. Vahtoss try out his mind-transference device. Hilarity ensues when the two switch bodies. Chairface Chippendale moves in to try and steal the device and soon everyone is switching with everyone.
Sewer Urchin battles his arch enemy, the Sewer Czar, earning the respect of his fellow superheroes.
Mr. Mental steals a device from Dr. Pendecker that lets him hypnotize Arthur and the Tick into thinking he's a baby so they'll protect him. Unfortunately, Mental leaves the device in the taxi and has to recover it.
The Mustache, a U.S. secret weapon, escapes from the lab and tries to team up with its counterpart, the Russian Beard. In hot pursuit are Jim Rage and the Ladies of Project: Shave, so the Mustache takes refuge on the Tick's lip. Meanwhile, Dinosaur Neil and Dot plan for their marriage.
Attention Evil-doers! The Tick is here, and he’s wearing the blue tights of justice! Together with his trusty moth-costumed sidekick Arthur, The Tick keeps the streets of The City safe from a rogue’s gallery of hilariously malevolent villains. So grab a snack, put your feet up and get ready to laugh and cheer as everyone’s favorite brawny hero swats evil on the snout with the rolled-up newspaper of goodness!