Mr. Webb (Mark Richman), a THRUSH agent, and Margitta Kingsley (Eleanor Parker), the wife of U.N.C.L.E. agent Robert Kingsley (Barry Sullivan), plot to steal a docility gas from General Maximilian Harmon (Leslie Nielson), who has kidnapped Professor David Garrow (Dan O'Herlihy) and his son Steve (Tony Bill). Harmon and a group of scientists consider themselves the ""Seven Intellectual Wonders of the World"" and, with the gas and the troops, plan to take over control of the world and ensure peace.
Mr. Webb (Mark Richman), a THRUSH agent, and Margitta Kingsley (Eleanor Parker), the wife of U.N.C.L.E. agent Robert Kingsley (Barry Sullivan), plot to steal a docility gas from General Maximilian Harmon (Leslie Nielson), who has kidnapped Professor David Garrow (Dan O'Herlihy) and his son Steve (Tony Bill). Harmon and a group of scientists consider themselves the ""Seven Intellectual Wonders of the World"" and, with the gas and the troops, plan to take over control of the world and ensure peace.
Illya goes to U.N.C.L.E.'s secret island training academy, the Survival School, to help Jules Cutter (Richard Beymer) find a THRUSH infiltrator who has assassinated a trainee. Suspicion focuses on three trainees Melisa Hargrove (Susan Odin), John Saimes (Chris Robinson), and Harry Williams (Charles McGraw), and Illya must find out who is the real double agent.
A dying UNCLE agent warns Napoleon and Illya that a group of supermen is being bred by THRUSH. The duo discover a school set up by the enemy organization in Mexico, who has already produced 7 emotionless killer students! As a graduating exercise, one is chosen to eliminate Solo and Kuryakin after they follow the boy to Austria.
Agents Napoleon Solo and Illya Kuryakin work for a secret intelligence service working under the auspices of the U.N. Their immediate superior is Mr. Waverly. Together they operate out of a secret base beneath the streets of New York City, and accesses through several cover business such as Del Floria's Tailor Shop and the Masque Club. This secret intelligence service is called U.N.C.L.E. United Network Command for Law and Enforcement.