Just when Lily thinks life can't get any more complicated, her mother begins to show early signs of Alzheimer's disease.
The prospect that Grace may be romantically involved with her creative-writing teacher troubles Lily, infuriates Jake, and imperils the career of the instructor.
When Lily's brother Aaron expresses a desire to move out on his own with a young woman who is also mentally disabled, she finds it emotionally impossible to let him go.
Sam places his dream of committing to Judy and having a family squarely on the shoulders of his ten-year-old son. Meanwhile, Jake finally realizes his feelings for Tiffany and his new baby daughter.
Grace pursues her teacher and Jessie develops an attraction for her friend Katie.
Jessie's anxiety and guilt about her mom's slow recovery causes tension with every member of the family, especially Lily. Meanwhile, Eli is in denial about the seriousness of his mother's condition.
A tragic accident shakes Karen from her deep depression and sets her up for the toughest battle of her life. This makes Eli and Jessie learn the hard way that their parents are more fragile than they'd thought.
Amid complete chaos, a surprise Christmas Eve delivery of Tiffany and Jake's baby unites the Manning and Sammler families like never before. Meanwhile, Judy's first encounter with Sam's eleven-year-old son doesn't go very smoothly.