Connor and Powell must travel to a small Mexican town after an earthquake strikes, trapping Natalie, Eva, and Miles. Only when they go after Miles, who was trapped in the church Mission La Roca, they are captured by insurgents.
The team travels to Baltimore to help stop an outbreak of the plague, a disease that wiped out much of Europe in the middle ages. But they uncover a string of dirty cops, who were trying to cover up a murder, in the process.
The team is trapped in a snowstorm in the arctic while trying to figure what is causing pneumonia in patients that also causes psychosis. To make matters worse, one of their own goes down with the same illness.
A smallpox outbreak sends the NIH team to Montana. However, is this once thought to have been eradicated disease caused by terrorism, or is it natural?
A surfer and volleyball player from a seaside town catch a mysterious disease. Dr. Connor and his staff begin suspecting that nearby seals played a part in this illness, however are the other forces at play?
An ""Angel of Death"" runs amok in a hospital, spreading a deadly flesh eating virus, which kills patients. Now it is up to the NIH to stop this lunatic, who has a past that they should not be proud of.
The team flies to a small Virgina town to figure out why people are dying from a deadly strain of the flu.
The team flies to Philadelphia to figure out if Anthrax is showing up as a result of terrorism or not.
Medical Investigation was an American medical drama television series that began September 9, 2004, on NBC. It ran for 20 one-hour episodes before being cancelled in 2005. The series was co-produced by Paramount Network Television and NBC Universal Television Studio The former controls North American distribution rights, while the latter distributes outside North America. The series featured the cases of an elite team of medical experts of the National Institutes of Health who investigate unusual public-health crises, such as sudden outbreaks of serious and mysterious diseases. In actuality, medical investigative duties in the United States are normally the responsibility of the Centers for Disease Control and Prevention and local health departments, while the NIH is primarily a disease-research and -theory organization. The series existed in the same television universe as Third Watch and, by extension ER. A special two-part crossover event aired on February 18, 2005, establishing the television-universe connection by featuring the Third Watch and Medical Investigation teams working together in MI's Episode 17: "Half Life" and Third Watch's Episode 16 of the sixth season: "In the Family Way". The story was about a series of Marburg virus cases in New York.