A man trying to check himself into the psych ward claims to be a werewolf. Meanwhile, Nora has a difficult decision to make, and Jack sees a therapist about his recent problems.
A factory worker has a few fingers chopped off yet refuses to have surgery to reattach them. Meanwhile, Jack argues with his colleagues over Veronica being assigned his sister Becky's case of schizophrenia.
Jack and his schizophrenic sister are reunited, and makes her treatment his top priority. Meanwhile, Jack is asked for help by Veronica in treating an Iraq War veteran who is suffering from post-traumatic stress disorder and amnesia.
Jack's patient is a 16-year old girl who is suicidal and has a deep dark secret which has been held from her since birth. Meanwhile, Jack and Dr. Avidan's relationship deepens, and he continues his search for his schizophrenic twin sister continues.
A patient makes a return when it seems his OCD and Tourette's Syndrome has worsened, causing his wife to push for unproven brain surgery, which makes the team believe the wife may have issues of her own. Meanwhile, Jack becomes infatuated with a neurosurgeon.