Spider-Man realizes that the diabolical Gaines Twins have brain-blasted him into believing that MJ has died at the hands of Kraven the Hunter. He corners the Twins, but things take a turn for the worse when they once again use their telepathy to trick him.
Spider-Man battles Turbo Jet, a modern-day Robin Hood armed with a homemade propulsion system, who steals from the wealthy and gives to the poor. Spidey's life gets even harder as the public rallies around Turbo Jet – and against Spider-Man.
Spider-Man is duped by the infamous Kingpin into stealing the TX-1 super-chip, designed to decrypt the confidential satellite transmissions that drive the world's financial markets. Now he must find a way to get it back.
Peter covers a press conference and inadvertently videotapes incriminating evidence against Silver Sable, an Eastern European assassin for hire. Now she will stop at nothing — including killing Mary Jane, Harry, and Indy — to get the tape back.
Electro returns from his seeming death and tries to make Sally, a girl he has a crush on, become an electrical being just like him.
A team of three ex-KGB agents called Pterodax take people hostage, including Peter and Indy, his new crush. They want Spider-Man, so Peter must figure out a way to appease Pterodax without revealing his alter ego.
Spider-Man is out to catch Talon, a female thief who is responsible for high-risk robberies in the city. Things get complicated when Spidey finds out that Talon is his best friend Harry's new girlfriend.
Peter's professor, Doc Connors, injects himself with reptilian DNA, which slowly changes him into the angry, vengeful Lizard; and since the serum affects Doc Connors' brain, Spider-Man must stop his beloved professor as he begins seeking revenge on those who have harmed him, including Harry.