After her stint in the hospital, Miss Piggy and Kermit reevaluate their relationship, and Kermit turns to Jack White (The White Stripes) for advice.
When Miss Piggy breaks her leg rehearsing a dance number, Kermit gathers the crew and they broadcast “Up Late” from the hospital. Back at the studio, Rizzo, Pepe and Yolanda find creative ways to keep Pache occupied so he doesn’t ruin the show while Kermit is out.
Sparks fly when Kermit and Miss Piggy pretend that they are back together for the sake of Kermit’s impressionable nephew Robin. And now that Camilla is taking up all of Gonzo’s time, Pepe and Rizzo audition for a replacement wingman.
Miss Piggy goes to an aerial silks class in at attempt to make new friends and Gonzo, Pepe and Rizzo fall under Pache’s spell.
When Miss Piggy suffers a scandalous wardrobe malfunction, the network is outraged, and Piggy is forced to question everything she stands for, but Kermit and the gang rally together and come to her defense. Meanwhile, Gonzo misses his ex-girlfriend Camilla, so Pepe and Rizzo decide to throw a house party to cheer him up.
After a show-stopping duet with Miss Piggy on “Up Late with Miss Piggy,” Joseph Gordon-Levitt joins Scooter, Pepe, and the gang for poker night. The Great Gonzo gears up to perform his dream stunt and Dave Grohl challenges Animal to a drum-off.
Kermit is feeling the pressure at work and is forced to go to a private Yoga retreat where he runs into a stressed out Jason Bateman. Meanwhile, with Kermit out of the office, Scooter is left to run the show and things go from bad to worse.
Kermit is scrambling to find the perfect birthday gift for Denise, so he turns to Miss Piggy for help. Meanwhile, Kristin Chenoweth agrees to do a gig with The Electric Mayhem and inadvertently causes a rift between the band.
Miss Piggy and Reese Witherspoon have a heated rivalry but when the two volunteer for Habitat for Humanity, their feud escalates to a whole new level. Meanwhile, Fozzie and his girlfriend hit a rough patch.
Fozzie takes things a little too far when Kermit offers him advice and Nick Offerman steps in to help the gang. Meanwhile, Christina Applegate guests on “Up Late,” and brings Miss Piggy a sweet surprise that doesn't go over well and Pepe, Rizzo and Liam Hemsworth try to help Gonzo out with his online dating situation.
In an attempt to make Miss Piggy happy, Kermit sets her up with Josh Groban who fills her head with ideas on how to make Up Late with Miss Piggy better. Meanwhile, Fozzie is invited to a party at Jay Leno’s house and everyone is annoyed that Bobo is selling cookies for his daughter’s troop.
Miss Piggy is furious that Kermit booked Elizabeth Banks as a guest on her late night talk show Up Late with Miss Piggy, Fozzie Bear meets his girlfriend’s parents, and Grammy Award-winning rock band Imagine Dragons performs their new single “Roots”.
The Muppets return to primetime with a contemporary, documentary-style show. For the first time ever, a series will explore the Muppets’ personal lives and relationships, both at home and at work, as well as romances, breakups, achievements, disappointments, wants and desires. This is a more adult Muppet show, for “kids” of all ages.