When a student is found murdered, Pierce tries to find the killer while defending the victim's boyfriend; Pierce must confront his feelings as Kate and Donnie prepare for their wedding day.
Pierce and Moretti uncover an international scandal while investigating the murders of a Bangladeshi diplomat and a Chicago reporter; Moretti struggles with the preparations for her upcoming wedding.
Agent Kate Moretti goes under cover to investigate an animal rights group suspected of foul play; Pierce considers making a confession to Kate.
After Dr. Daniel Pierce suffers a traumatic injury, his father and his friend must decide if they should allow him to undergo a high-risk surgery; Pierce begins to question everything he sees and hears.
Moretti calls on Pierce to examine Elena Douglas, a woman who has confessed to murder and claims to be possessed by the Devil. Meanwhile, Donnie and Moretti’s wedding plans hit a bump in the road.
Dr. Daniel Pierce, a neuroscientist and professor, is recruited to help the federal government crack difficult cases. His intimate knowledge of human behavior and masterful understanding of the mind give him an extraordinary ability to read people, but his eccentric view of the world and less-than-stellar social skills can often interfere with his work.