Conrad is pulled away from celebrating Gigi’s 6th birthday when Sammie comes into Chastian with a 104-degree fever, and Kit must call in a favor for treatment. Meanwhile, a heart arrives for Governor Betz’s transplant surgery.
The ER quickly fills up after a heavy storm causes a devastating helicopter crash. Conrad, Devon and the rest of the Chastain doctors rush to treat patients including the helicopter pilot, a barista, and Chastain’s least favorite person, Governor Mark Betz.
Devon prepares to perform the first titanium rib cage implant surgery in the country.
After a teenage boy is taken into Chastain for falling unconscious from a suspicious pill, Conrad takes action to find the boy's brother before he meets the same fate. Meanwhile, Dr. Bell deals with being served court papers from a former patient.
Devon sees a traveling British couple who are nervous about the cost of American health care.
On the day of Kit and Bell’s wedding, Bell and Conrad get pulled away to tend to the ill daughter of a major hospital donor. Meanwhile, Billie takes Gigi and Sammie dress shopping.
A college professor comes into the ER and Conrad realizes it’s a former patient of his from when he was an intern. Meanwhile, Devon ends up admitting a man – who swears by an anti-aging regimen that he thinks is the answer to eternal life – into the hospital after he collapses.
Ian is faced with performing a surgery on a Jane Doe NICU patient while he continues to struggle with his personal issues. Meanwhile, Conrad asks Devon to cover his shift so he can spend a day at home with an anxious Gigi.