After receiving a message containing clues on Tweetums' whereabouts, the Loonatics and Sylth Vester seek out where Tweetums is. Meanwhile, General Deuce and Optimatus begin their plans to conquer the universe.
An old friend of Danger Duck, Officer Pinkster Pig, helps the Loonatics in their fight against gangsters Stoney the Stone and Bugsy the Bug. But since he helps, things have been going bad for the Loonatics.
Stomper is on the loose, and it is up to Danger Duck to fight against this new villain.
After the Loonatics' mission on stopping Toby the Pizza Boy possessed by a Bio-Tech Brain Parasite device, Rev Runner's family comes to visit when they want Rev to take over the family business. When Rev's brother Rip finds the confiscated Bio-Tech Brain Parasite, The Loonatics must stop him.
The Loonatics have to transport Tweetums, the heir to the throne, to his home planet to end a war. Little do they know is that they are threatened by a force named Sylth Vester and an unknown figure. Both will stop at nothing to see they don't complete their mission.
Pierre Le Pew convinces Slam and Duck that Slam can become a champion fighter in his private tournament. However, he fails to tell them that the last match is to the death. It's up to the rest of the Loonatics to save Slam before it's too late.
The Loonatics encounter Adolpho, a mutated dolphin who uses psychic abilities to brainwash sea creatures and destroy any human-made object at sea. It's up to the Loonatics to stop Adolpho and his gang of killer dolphins from taking revenge on the "surface-dwellers" at their next target: Acmetropolis.
Ace meets a mysterious young man, Deuce, who saves his life when Ophiuchus Sam attempts to rob an interdimentional train. But Deuce is not who he appears, and Ace learns the true origins of his sword.
Loonatics Unleashed is an American animated television series produced by Warner Bros. Animation that ran on the Kids' WB for two seasons from 2005 to 2007 in the United States, Teletoon in Canada, Kids Central in Singapore, Cartoon Network's Boomerang in Australia, Cartoon Network in the UK, Southeast Asia and Latin America, and XHGC in Mexico. It is still broadcasting on Clan TVE. The series was loosely based on the Looney Tunes cartoon characters, with the series described by Warner Bros. as an "action-comedy." Loonatics Unleashed is meant to be a mixture of the Looney Tunes shorts' irreverent style of humor and a modern action animated series, with the characters designed in an anime inspired style.