When Mac and Riley go missing and wake up 24 hours later in a corn field with no memory of how they got there, they must unravel the mystery to find who took them, and how to get rid of the nanotrackers in their bodies, no matter the cost.
Mac and Desi travel with Bozer to his childhood home when his aunt dies in a tragic accident, however, they soon discover she may have been murdered for trying to expose the city’s contaminated water supply. Also, Riley, Matty and Russ continue to follow leads on their nano-trackers investigation.
While Mac and the team delve into the world of Italian car culture in order to track down a crime boss-in-hiding, Mac must lean on Desi when he discovers that he losing the ability to control his hands. Also, Mac and Desi move in together and Riley reveals the truth about her secret team of hackers to Russ.
Mac, Desi and Russ go undercover during a royal Indian wedding to protect a princess whose policies could put her life in danger. Also, Russ and Sophia come face-to-face at the wedding, Bozer suspects Riley is up to her old hacking ways and Matty runs down a lead in hopes of getting to the bottom of Mac and Riley’s ingested nano-trackers,
Mac and Riley head overseas together to prevent a governmental collapse and inadvertently inhale new deadly microscopic technology.
While on a mission to hunt down a Codex lead, Mac and the team discover Murdoc hacked their comms and has recorded them for months. Now, Mac and the team must stop Murdoc, who is working with Andrews, as they plot to kill thousands and reveal each Phoenix member’s most-guarded secrets.
When Mac and the team are unable to prevent Department of Defense intel from falling into Codex’s hands, Mac must scale a vertical cliff using only gear he can cobble together himself to prevent the info’s transmission.
Mac and team rush to help when Matty’s former mentor, Ian Cain, and his embassy staff come down with a deadly, mysterious illness. Taylor and Bozer work with Jerry Ortega to infiltrate a Codex cell.
The secret experimental cancer treatment Mac’s developing with a friend is discovered when culprits ransack their lab, kidnap Mac’s partner and plan to use the research to create a powerful new nerve agent.
During COVID-19’s first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor’s house. Also, Russ’ romantic fling takes on a longer and more complicated turn when they quarantine together.
Using a cryptic postcard as their only clue, Mac and the team must solve a fallen friend’s final case and bring him justice.
Mac's meeting with Desi's parents goes sideways when her brother finds himself in trouble and desperately needs their help. Also, Russ and Matty must ask an old nemesis for assistance when their new recruitment candidate is kidnapped.
When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him. Also, while on the run, Mac and Desi are forced to confront their relationship issues.
When Taylor’s former protégé is killed while preventing a bio-weapon from falling into the wrong hands, Mac and the team must find the weapon so Desi can pull off the ultimate heist before it’s sold to a terrorist cell.
Mac and the team infiltrate a glamorous hotel used as an international hideout for criminals to find a woman with vital information on Codex. However, their target has a new secret identity, including a completely new face.
20-something Angus MacGyver creates a clandestine organization where he uses his knack for solving problems in unconventional ways to help prevent disasters from happening.