The Flash, the fastest man alive, is tasked with his greatest challenge yet, to save the timeline and save existence. Friends old and new gather for an epic battle to save Central City, one last time.
Team Flash works together to figure out how to protect Barry, all while being very careful who they trust. Cecile is skeptical of the plan after an unsuccessful attempt. Khione's confidence in Chester enables him to convince Cecile to try one more time.
Iris is alarmed by Barry's disappearance and Cecile assures her everything will be ok, but does she know that for certain? Team Flash is affected by a mysterious substance and Khione develops a better understanding of what she can and cannot control.
As Iris receives word of a career milestone, Barry is suddenly nowhere to be found. In trying to get back home, Barry runs across many familiar faces. Khione continues to figure out her powers, and Chester works on a suit for Allegra.
Team Flash throws a surprise birthday party for Barry, but things go terribly awry when Ramsey Rosso crashes the festivities.
As Barry and Iris prepare for their new life, luck changes for those in Central City. Cecile takes on a case with Allegra's help, involving a string of unfortunate – and highly unexpected – events. Meanwhile, Chester and the team work with Khione to figure out her abilities.
As the Red Death wreaks havoc on Central City, Barry and Iris come up with a plan and turn to Cecile for help. Barry is faced with what he thinks was his greatest mistake and the Red Death's greatest success. Khione wants to help Team Flash, but Barry can't risk losing her. Joe gives Barry a much-needed pep talk.
After being struck by lightning, CSI investigator Barry Allen awakens from a nine-month coma to discover he has been granted the gift of super speed. Teaming up with S.T.A.R. Labs, Barry takes on the persona of The Flash, the Fastest Man Alive, to protect his city.