The team races to stop the hybrids from breaching the barrier wall by shutting down the last beacon that draws them in.
After the team’s plane suffers a catastrophic accident in the hybrid zone, Dariela and Tessa set out on a rescue mission to save them.
As the team is trapped inside the plane by toxic spores surrounding them, complications arise during the delivery of Clementine’s baby.
After Jackson attacks Abigail, the team rushes to save her as her life hangs in the balance.
After Mitch’s alter ego, Mr. Duncan, attacks the team’s plane then flees, Jamie, Abe and Max set out to find him and help.
Abigail holds Jackson prisoner in order to extract information from him that is critical to her secret master plan, and the team faces a mid-air crisis when their plane experiences an electrical malfunction
The team sets out on a rescue mission for Abe and Dariela’s son, Isaac. Then, in search of information on a new hybrid, Mitch and Jamie travel to California, where they cross paths with a familiar face from their past.
Mitch seeks to rescue Clementine from her captors, and a glimpse into Jackson’s sister Abigail’s past reveals the origins of the hybrids.
While Jamie’s under arrest, she manages to manipulate Mitch and Logan into helping her hunt shepherds, members of a secretive group responsible for sterilizing humans
Abraham and Dariela reunite with the team as they try and stop the hybrids from taking over New York City.
Abraham and Dariela consider making a deal with Reiden Global for personal reasons, and Jamie and Clementine perform a risky surgery on Mitch.
Jackson and Logan discover a link between the hybrid attacks that occur in Portland and New York; Mitch is interrogated by a woman claiming to be his daughter, Clementine; and a new development in Abraham’s research into the sterility crisis endangers his family.
Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of “the hybrids,” an army of unstoppable lab-made creatures focused on destroying mankind.
Set amidst a wave of violent animal attacks sweeping across the planet, a young renegade scientist is thrust into a race to unlock the mystery behind this pandemic before time runs out for animals and humans alike.