As Carter prepares to open a new facility for the underprivileged, some old friends/colleagues gather. Rachel Greene, Mark Greene's daughter, applies for an internship at County.
The ER doctors and nurses help out at Camp Del Corazon, a camp for kids who have had open-heart surgery, working alongside the camp counselor.
On Neela's last day at County, she has doubts as to whether she is making the right decision.
Carter finds himself struggling with County's new technology and procedures. After becoming frustrated with the in vitro-fertilization, Banfield and her husband discuss adoption as an option. Sam's mother arrives in an altered state of mind.
It's Valentine's Day. Dr. John Carter is back at the County. Brenner and Neela are getting closer. Dr. Banfield is having a hard time trying to have a baby. And Puck and mushrooms may not be a good combination.
A mother is severely injured by a car accident in the ambulance bay; an insurance company frustrates Morris; Neela tells Brenner about her offer in North Carolina.
Morris and Gates treat an older man who was assaulted on the street; Sam gets a surprise visit from her sister; Dr. Morgenstern visits County General when he discovers an old mentor is ill.
Morris tries to help a girl who was hit while riding her bike; Gates can't get over his feelings for Sam; Neela is flustered when Dr. Brenner returns from Australia.
Neela has a recurring dream; Gates tries to save a patient who jumped out of a window while sleeping; Neela is surprised to see Dr. Corday.
Morris' father arrives at the ER's doorstep and leaves him an unwanted package. Sam wants Alex to get off the ventilator as quick as possible following his accident. Meanwhile, a woman is in danger of being deported despite her high-risk pregnancy.
Banfield and Morris go to the coffee shop at 3 a.m. and are served by 20-year-old Debbie who is six-months pregnant. The doctors treat someone with a heart problem and Alex. Chaz must look for a missing 7-year-old boy who saw his sister die.
Dr. Banfield is irritated when Morris takes Chaz under his wing and teaches him risky medical procedures; Neela is unhappy when Dr. Banfield undermines her authority with an intern.
Banfield is caught off guard when a man tries to steal her wallet; Dr. Dubenko returns to the surgery team; a family member is suspected of hurting a young gymnast; Sarah gets her tongue pierced.
Neela is upset when she finds out Abby's good news second hand; the new chief, Catherine Banfield, and Abby disagree on how to treat a gunshot wound victim; Abby defends Sam when she goes before a nurses disciplinary board.
Everyone in the ER is trying to cope with the loss of their colleague. The staff feels defensive toward the new Chief and her tough disposition. Gates and the new interns treat a bio terrorist, who has a lethal secret that endangers them all. Neela makes a great effort to get Dubenko back on the surgery staff, and gets help from an unexpected souce.